Image credit: Dr. Laurent Moreaux (Caltech) and Dr. Stephan Junek (Max Planck Institute for Brain Research).
This effort will place into the hands of many experimental neuroscientists validated, massively-multiplexed tools for:
i) stimulating and recording neuronal activity,
ii) local, e.g. layer-specific, chemical sensing of neuromodulators, and
iii) highly-patterned optogenetic stimulation with concurrent electrical recording.
All of of our probe architectures are designed to be implanted in regions deep within the brain.
These advanced neurotechnological systems – which are based upon our validated implantable neural nanoprobes and advanced, custom microchips for their readout and control – will be successively enhanced, mass-produced, and disseminated over the course of this effort. The implantable, multi-site nanoprobe layer modules that we fabricate are stackable into composite 3D systems with thousands of full time/full bandwidth channels. The various probe architectures enable systems for electrophysiological stimulation (Estim), recording (Ephys), and local electrochemical sensing of neuromodulators (Echem).
We are also developing implantable photonic probes that co-integrate arrays of microscopic emitter pixels (Epix) for local optogenetic stimulation with proximal multisite electrophysiological recording.
"Alpha" (early) adopters are providing direct feedback to enable iterative refinement of nanoprobes and readout electronics.The alpha adopter community will also assist these efforts by developing open-source protocols (for probe preparation and implantation), open-source hardware (for implantation stages, headstage packaging, and high-compliance cabling), and open-source software (for data analysis). Together this optimized hardware and software will be disseminated to a much broader group of "beta" adopters worldwide.
17 October 2017
Our Gen-2 probes, slated for dissemination in December 2017, are described on our Probes page.
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Kavli Futures Symposium: TOWARD OPEN-SOURCE NEUROTECHNOLOGY DISSEMINATION
20-21 October 2017
Symposium website: kfs-neurotech.org
Co-Organizers: Ed Boyden (MIT), Miyoung Chun (Kavli Foundation),
Michael Roukes (Caltech, chair), Ken Shepard (Columbia)
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For Caltech's Winter 2017 Course: "Probing Brain Function with Light", click here.
30 October 2017
Our Gen-2 probes are now beginning to be characterized by our alpha adopter group!